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Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation.

机译：髓鞘碱性蛋白在髓鞘形成之前在少突胶质细胞中被免疫细胞化学证实。

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摘要

A specific antibody to myelin basic protein has been used to localize the protein in developing rat oligodendroglia and myelin. Basic protein is found in the oligodendroglial cytoplasm of anterior commissures of 5- and 7-day old rats before the beginning of myelination. Staining of basic protein in oligodendroglia increases, becoming most intense during early myelination; it decreases during rapid myelination. Staining intensity of oligodendroglia is dependent upon age, brain region, and nervous tract studied. In myelin, reaction of basic protein with antibody decreases when large compact sheaths are present, unless tissue sections are first treated with alcohol.

机译：已使用针对髓磷脂碱性蛋白的特异性抗体将蛋白定位在发育中的大鼠少突胶质和髓磷脂中。在开始髓鞘形成之前，在5日龄和7日龄大鼠的前连合的少突胶质细胞质中发现了碱性蛋白。少突胶质细胞中碱性蛋白的染色增加，在早期髓鞘形成过程中最强烈。在快速髓鞘形成过程中减少。少突胶球菌的染色强度取决于年龄，大脑区域和神经道。在髓磷脂中，除非存在首先用酒精处理的组织切片，否则当存在大而紧凑的鞘时，碱性蛋白与抗体的反应会降低。

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作者
Sternberger, N H; Itoyama, Y; Kies, M W; Webster, H D;
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年度 1978
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正文语种 en
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专利

1. Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia. [J] . Nakahara J, Tan-Takeuchi K, Seiwa C, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2001,第3期

机译：髓鞘碱性蛋白对于调节小鼠少突胶质中髓鞘相关糖蛋白表达是必需的。
2. Phase separation of myelin sheath in Triton X-114 solution: Predominant localization of the 21.5-kDa isoform of myelin basic protein in the lipid raft-associated domain [J] . UruseM., YamamotoM., SugawaM., The Journal of Biochemistry . 2014,第4期

机译：Triton X-114溶液中髓鞘的相分离：髓磷脂相关结构域中髓鞘碱性蛋白的21.5-kDa亚型的主要定位
3. Myelin-Basic Protein-reactive Specific CD4(+) and CD8(+) NK Lymphocytes Induce Morphological Changes in Neuronal Cell Bodies and Myelin Sheaths: Implications for Multiple Sclerosis. [J] . Quan-Yu Z, Jing-Hui H, Hong-Zeng L, Archives of medical research . 2008,第1期

机译：髓磷脂碱性蛋白反应性特异性CD4（+）和CD8（+）NK淋巴细胞诱导神经元细胞体和髓鞘的形态变化：对多发性硬化症的影响。
4. T cell receptor altered peptide ligands of Myelin Basic Protein and Proteolipid Protein (Linear and Cyclic) can modulate immune responses in SJL/J mice: Bioactive peptides for Multiple Sclerosis [C] . Maria Katsara, Theodore Tselios, Spyros Deraos International Peptide Symposium . 2009

机译：T细胞受体改变髓鞘碱性蛋白质和蛋白质（线性和环状）的肽配体可以调节SJL / J小鼠中的免疫应答：用于多发性硬化的生物活性肽
5. Myelin basic protein (MBP): Membrane adhesion and domain formation. [D] . Musse, Abdiwahab Abdul. 2008

机译：髓磷脂碱性蛋白（MBP）：膜粘附和结构域形成。
6. Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation. [O] . N H Sternberger, Y Itoyama, M W Kies, 1978

机译：髓鞘碱性蛋白在髓鞘形成之前在少突胶质细胞中被免疫细胞化学证实。
7. Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat. [O] . Sternberger, N H, Quarles, R H, Itoyama, Y, 1979

机译：髓磷脂相关糖蛋白在发育中的大鼠的髓磷脂和形成髓鞘的细胞中通过免疫细胞化学证实。
8. Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema [R] . Veronesi, B., Jones, K., Gupta, S., 1991

机译：髓磷脂碱性蛋白 - 信使RNa（mBp-mRNa）在三乙基锡诱导的髓鞘水肿期间的表达

Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation.

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